The R10K project aims to sequence the immune repertoire of 10,000 samples that represent 100 diseases. Our goal is to identify disease-specific T or B cell receptor sequences for improving diagnosis, prognosis and treatment management. 

The immune repertoire is the sum of T and B cells in a body at any given moment. It is both a snapshot and a historical record of a person’s immune functions. Sequencing the expressed T-cell receptor genes in the immune repertoire enables an accurate evaluation of a person’s health status and disease risks.

The R10K project, led by the nonprofit HudsonAlpha Institute for Biotechnology, is an international, collaborative effort. Our scientific advisory board helps establish guidelines for proposal submission and evaluates potential studies. Initially, four categories of diseases and conditions are being studied: cancer, autoimmune diseases, inflammatory diseases and infectious diseases/vaccines.

Researchers are encouraged to submit a short proposal. Once selected, the R10K project will fund the proposed study by providing free reagents to generate immune repertoire libraries, conducting high throughput sequencing and performing data analysis. 

Scientists leading successful proposals will be able to publish the data and analyses. For the rest of the community, the sequencing data will be released six months after the data set has been generated.
 

Request For Proposals : The proposal guidelines are available to download.

The Repertoire 10K (R10K) Project:

Jian Han, MD., Ph.D., Project Director. HudsonAlpha Institute for Biotechnology. 

Richard Myers, Ph.D., Chairman of the Scientific Advisory Board,. HudsonAlpha Institute for Biotechnology.

Douglas T. Ross, MD., Ph.D. Scientific Director. HudsonAlpha Institute for Biotechnology.

Chunlin Wang, Ph.D., Director of Informatics. Stanford Genome Technology Center. 

Shawn Levy, Ph.D., Director of Sequencing. HudsonAlpha Institute for Biotechnology.

Executive Directors